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Citrus fruits

The flavonoids of citrus fruits have been investigated due to their biological activities (such as anti-inflammatory, anti-carcinogenic and antitumor effects).

The majority of citrus species accumulate large quantities of flavonoids during their development. All flavonoids described in Citrus sp. can be classified in the following groups: flavanones, flavones and flavonols.  Naringin (naringenin 7-0-neohesperidoside), a glycoside of flavanone, is particularly prevalent in grapefruit (C. Paradisi) and is responsible for the sour taste of grapefruit juice. Narirutine (naringenin-7-0-rutinoside) is also present in grapefruit but to a lesser degree.

Phenolic compounds are undergone to intestinal/hepatic metabolism; molecular forms that reach the peripheral circulation and tissues are different from those in foods. Generally, predominant structures in plasma are conjugated (glucuronide or sulfate, with or without methylation). These compounds are chemically different from their parents, differing in size, polarity and ionic form, which denotes that its physiological conduct may be different.

We are currently identifying the presence of these compounds in extracts of citrus fruits and evaluating their absorption in biological samples after oral administration.

 

GROUP PUBLICACTIONS:

  • Trzeciakiewicz A, Habauzit V, Mercier S, Barron D, Urpi-Sarda M, Manach C, Offord E, Horcajada MN. Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation. J Agric Food Chem. 2010;58(1):668-75.
  • Martínez-González MA, Lamuela-Raventos RM. The unparalleled benefits of fruit. Br J Nutr. 2009;102(7):947-8. 
  • Mata-Bilbao Mde L, Andrés-Lacueva C, Roura E, Jáuregui O, Escribano E, Torre C, Lamuela-Raventós RM. Absorption and pharmacokinetics of grapefruit flavanones in beagles. Br J Nutr. 2007;98(1):86-92.
  • Mata Bilbao ML, Andres-Lacueva C, Jáuregui O, Lamuela-Raventós RM. Determination of flavonoids in a Citrus fruit extract by LC-DAD and LC-MS. Food Chem. 2007:101(4):1742-7.
  • Medina-Remón A, Tulipani S, Rotchés-Ribalta M, Mata-Bilbao MD, Andres-Lacueva C, Lamuela-Raventos RM.A Fast Method Coupling Ultrahigh Performance Liquid Chromatography with Diode Array Detection for Flavonoid Quantification in Citrus Fruit Extracts. J Agric Food Chem. 2011:59(12):6353-6359.